Regulation of guanylate cyclase by a guanine nucleotide binding protein, G alpha 2, in Dictyostelium discoideum.

doi:10.1016/0006-291x(91)90419-8

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Article

Regulation of guanylate cyclase by a guanine nucleotide binding protein, G alpha 2, in Dictyostelium discoideum.

Biochemical and biophysical research communications - 15 May 1991

Oyama M, Kubota K, Okamoto K

Abstract excerpt

Binding of cyclic AMP (cAMP) to the cell surface receptor induces a transient activation of guanylate cyclase in Dictyostelium discoideum. A frigid mutant (HC85) which lacks G alpha 2, a guanine nucleotide binding protein, does not respond to cAMP. We found that 2,3-dimercapto-1-propanol (BAL) in...

Topics

Cold Temperature
Cyclic AMP
Dictyostelium
Dimercaprol
Enzyme Activation
GTP-Binding Proteins
Guanylate Cyclase
Kinetics
Mutation

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