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Article

Rare nonsynonymous exonic variants in addiction and behavioral disinhibition.

Biological psychiatry - 15 May 2014

Vrieze Scott I, Feng Shuang, Miller Michael B, Hicks Brian M, Pankratz Nathan, Abecasis Gonçalo R, Iacono William G, McGue Matt

Abstract excerpt

BACKGROUND: Substance use is heritable, but few common genetic variants have been associated with these behaviors. Rare nonsynonymous exonic variants can now be efficiently genotyped, allowing exome-wide association tests. We identified and tested 111,592 nonsynonymous exonic variants for association with behavioral disinhibition and the use/misuse of nicotine, alcohol, and illicit drugs. METHODS: Comprehensive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24094508
DOI: 10.1016/j.biopsych.2013.08.027
PMCID: PMC3975816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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