Article
Cannabinoid receptor 1 gene association with nicotine dependence.
Archives of general psychiatry - 1 Jul 2008
Chen Xiangning, Williamson Vernell S, An Seon-Sook, Hettema John M, Aggen Steven H, Neale Michael C, Kendler Kenneth S
Abstract excerpt
CONTEXT: The endogenous cannabinoid system has been implicated in drug addiction in animal models. The cannabinoid receptor 1 (CNR1) gene is 1 of the 2 receptors expressed in the brain. It has been reported to be associated with alcoholism and multiple drug abuse and dependence. OBJECTIVE: To test the hypothesis that the CNR1 gene is associated with nicotine dependence. DESIGN: Genotype-phenotype association...
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