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Article

Global analysis of gene function in yeast by quantitative phenotypic profiling.

Molecular systems biology - 1 Jan 2006

Brown James A, Sherlock Gavin, Myers Chad L, Burrows Nicola M, Deng Changchun, Wu H Irene, McCann Kelly E, Troyanskaya Olga G, Brown J Martin

Abstract excerpt

We present a method for the global analysis of the function of genes in budding yeast based on hierarchical clustering of the quantitative sensitivity profiles of the 4756 strains with individual homozygous deletion of nonessential genes to a broad range of cytotoxic or cytostatic agents. This method is superior to other global methods of identifying the function of genes involved in the various DNA repair and...

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Identifiers

PMID: 16738548
DOI: 10.1038/msb4100043
PMCID: PMC1681475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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