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Article

<i>Lkb1</i> Deficiency Causes Prostate Neoplasia in the Mouse

1 Apr 2008

Abstract excerpt

Mutation of LKB1 is the key molecular event underlying Peutz-Jeghers syndrome, a dominantly inherited condition characterized by a predisposition to a range of malignancies, including those of the reproductive system. We report here the use of a Cre-LoxP strategy to directly address the role of Lkb1 in prostate neoplasia. Recombination of a LoxP-flanked Lkb1 allele within all four murine prostate lobes was...

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Identifiers

PMID: 18381428
DOI: 10.1158/0008-5472.can-07-5169

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