Article
The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy.
Molecular and cellular biology - 1 Jun 2006
Chen Xin, Shevtsov Sergei P, Hsich Eileen, Cui Lei, Haq Syed, Aronovitz Mark, Kerkelä Risto, Molkentin Jeffery D, Liao Ronglih, Salomon Robert N, Patten Richard, Force Thomas
Abstract excerpt
In cells capable of entering the cell cycle, including cancer cells, beta-catenin has been termed a master switch, driving proliferation over differentiation. However, its role as a transcriptional activator in terminally differentiated cells is relatively unknown. Herein we utilize conditional, cardiac-specific deletion of the beta-catenin gene and cardiac-specific expression of a dominant inhibitory mutant of...
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