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Article

Transcription Factor 7-like 2 Mediates Canonical Wnt/β-Catenin Signaling and c-Myc Upregulation in Heart Failure

1 Jun 2016

Abstract excerpt

BACKGROUND: How canonical Wnt/β-catenin signals in adult hearts, especially in different diseased states, remains unclear. The proto-oncogene, c-Myc, is a Wnt target and an early response gene during cardiac stress. It is not clear whether c-Myc is activated or how it is regulated during heart failure. METHODS AND RESULTS: We investigated canonical Wnt/β-catenin signaling and how it regulated c-Myc expression in...

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PMID: 27301468
DOI: 10.1161/circheartfailure.116.003010

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