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Article

Cardiac tissue-specific repression of CELF activity disrupts alternative splicing and causes cardiomyopathy.

Molecular and cellular biology - 1 Jul 2005

Ladd Andrea N, Taffet George, Hartley Craig, Kearney Debra L, Cooper Thomas A

Abstract excerpt

Members of the CELF family of RNA binding proteins have been implicated in alternative splicing regulation in developing heart. Transgenic mice that express a nuclear dominant-negative CELF protein specifically in the heart (MHC-CELFDelta) develop cardiac hypertrophy and dilated cardiomyopathy with defects in alternative splicing beginning as early as 3 weeks after birth. MHC-CELFDelta mice exhibit extensive...

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Identifiers

PMID: 15988035
DOI: 10.1128/MCB.25.14.6267-6278.2005
PMCID: PMC1168813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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