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Article

TGFβ-inducible early gene-1 (TIEG1) mutations in hypertrophic cardiomyopathy.

Journal of cellular biochemistry - 1 Jun 2012

Bos J Martijn, Subramaniam Malayannan, Hawse John R, Christiaans Imke, Rajamannan Nalini M, Maleszewski Joseph J, Edwards William D, Wilde Arthur A M, Spelsberg Thomas C, Ackerman Michael J

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiovascular disease. A recent study showed that male KLF10-encoded TGFβ Inducible Early Gene-1 knock-out mice (TIEG-/-) develop HCM with 13-fold up-regulation of PTTG1-encoded pituitary tumor-transforming gene 1. We hypothesized TIEG1 could be a novel candidate gene in the pathogenesis of genotype negative HCM in humans, possibly through a loss of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22234868
DOI: 10.1002/jcb.24058
PMCID: PMC3495561

Genes

PTTG1
KLF10
SMAD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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