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Article

Molecular analysis of major histocompatibility complex alleles associated with the lupus anticoagulant.

The Journal of clinical investigation - 1 May 1991

Arnett F C, Olsen M L, Anderson K L, Reveille J D

Abstract excerpt

Autoantibodies to phospholipids (APA) occur frequently in systemic lupus erythematosus (SLE) and other autoimmune disorders and predispose to intravascular thromboses. Major histocompatibility complex (MHC) class II alleles (HLA-DR and DQ) were determined by restriction fragment length polymorphisms (RFLP) in 20 patients with APA (lupus anticoagulant). HLA-DQw7 (DQB1*0301), linked to HLA-DR5 and -DR4 haplotypes,...

Topics

Alleles
Autoantibodies
Blood Coagulation Factors
HLA-DQ Antigens
HLA-DR Antigens
Humans
Lupus Coagulation Inhibitor
Lupus Erythematosus, Systemic
Phospholipids
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1673688
DOI: 10.1172/JCI115158
PMCID: PMC295227

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1673688-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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