Article
Molecular analysis of major histocompatibility complex alleles associated with the lupus anticoagulant.
The Journal of clinical investigation - 1 May 1991
Arnett F C, Olsen M L, Anderson K L, Reveille J D
Abstract excerpt
Autoantibodies to phospholipids (APA) occur frequently in systemic lupus erythematosus (SLE) and other autoimmune disorders and predispose to intravascular thromboses. Major histocompatibility complex (MHC) class II alleles (HLA-DR and DQ) were determined by restriction fragment length polymorphisms (RFLP) in 20 patients with APA (lupus anticoagulant). HLA-DQw7 (DQB1*0301), linked to HLA-DR5 and -DR4 haplotypes,...
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