Article
The DQw7 allele at the HLA-DQB locus is associated with susceptibility to IgA nephropathy in Caucasians.
Kidney international - 1 May 1991
Li P K, Burns A P, So A K, Pusey C D, Feehally J, Rees A J
Abstract excerpt
The frequencies of the MHC class II HLA-DR and DQ alleles in 36 Caucasian patients with IgA nephropathy (IgAN) were analyzed by RFLP analysis and allele specific oligonucleotide (ASO) probing of specifically amplified genomic DNA. The class II alleles HLA-DR4 (52.7%) and DR5 (30.5%) were increase...
Topics
- Alleles
- Base Sequence
- Blotting, Southern
- DNA
- Gene Frequency
- Glomerulonephritis, IGA
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- Humans
- Molecular Sequence Data
- Oligonucleotide Probes
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- White People