Article
The DQw7 allele at the HLA-DQB locus is associated with susceptibility to IgA nephropathy in Caucasians.
Kidney international - 1 May 1991
Li P K, Burns A P, So A K, Pusey C D, Feehally J, Rees A J
Abstract excerpt
The frequencies of the MHC class II HLA-DR and DQ alleles in 36 Caucasian patients with IgA nephropathy (IgAN) were analyzed by RFLP analysis and allele specific oligonucleotide (ASO) probing of specifically amplified genomic DNA. The class II alleles HLA-DR4 (52.7%) and DR5 (30.5%) were increased in the patient group compared to 1103 UK Caucasoid controls, but these increases were not statistically significant....
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