Article
HLA-DRB1*04/*13 alleles are associated with vascular disease and antiphospholipid antibodies in systemic lupus erythematosus.
Annals of the rheumatic diseases - 1 Jun 2013
Lundström Emeli, Gustafsson Johanna T, Jönsen Andreas, Leonard Dag, Zickert Agneta, Elvin Kerstin, Sturfelt Gunnar, Nordmark Gunnel, Bengtsson Anders A, Sundin Ulf, Källberg Henrik, Sandling Johanna K, Syvänen Ann-Christine, Klareskog Lars, Gunnarsson Iva, Rönnblom Lars, Padyukov Leonid, Svenungsson Elisabet
Abstract excerpt
BACKGROUND AND OBJECTIVES: Vascular disease is common in systemic lupus erythematosus (SLE) and patients with antiphospholipid antibodies (aPL) are at high risk to develop arterial and venous thrombosis. Since HLA class II genotypes have been linked to the presence of pro-thrombotic aPL, we investigated the relationship between HLA-DRB1 alleles, aPL and vascular events in SLE patients. METHODS: 665 SLE patients...
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