Article
Cytochrome P450-dependent metabolism and mutagenicity of 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one and their implications in its carcinogenicity.
Carcinogenesis - 1 Sept 1993
Boyd G W, Young R J, Harvey R G, Coombs M M, Ioannides C
Abstract excerpt
Methylation of the non-carcinogen 15,16-dihydrocyclopenta[a]phenanthren-17-one (CPP-17-one) at the bay region to form 11-CH3-CPP-17-one confers carcinogenic potential. In the present study we have investigated the in vitro metabolism and mutagenicity of the methylated compound by hepatic microsom...
Topics
- Animals
- Aroclors
- Chlorodiphenyl (54% Chlorine)
- Cytochrome P-450 Enzyme System
- Enzyme Induction
- Gonanes
- Male
- Microsomes, Liver
- Mutation
- Oxidation-Reduction
- Rats
- Rats, Wistar
- Spectrophotometry, Ultraviolet