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Article

Differential genetic associations and expression of PAPST1/SLC35B2 in bipolar disorder and schizophrenia.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jul 2022

Uezato Akihito, Jitoku Daisuke, Shimazu Dai, Yamamoto Naoki, Kurumaji Akeo, Iwayama Yoshimi, Toyota Tomoko, Yoshikawa Takeo, Haroutunian Vahram, Bentea Eduard, Meller Jarek, Sullivan Courtney R, Meador-Woodruff James H, McCullumsmith Robert E, Nishikawa Toru

Abstract excerpt

Lithium's inhibitory effect on enzymes involved in sulfation process, such as inhibition of 3'(2')-phosphoadenosine 5'-phosphate (PAP) phosphatase, is a possible mechanism of its therapeutic effect for bipolar disorder (BD). 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) is translocated from cytosol to Golgi lumen by PAPS transporter 1 (PAPST1/SLC35B2), where it acts as a sulfa donor. Since SLC35B2 was previously...

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PMID: 35501530
DOI: 10.1007/s00702-022-02503-7

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