Article
HLA DQ beta restriction fragment length polymorphism and rheumatoid arthritis. Association between DQw7 and rheumatoid arthritis in DR4-positive subjects.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde - 16 Mar 1991
Rousseau J, du Toit E D, Meyers O L, Ress S R
Abstract excerpt
Two variants of the HLA-DR4-linked DQw3 allele, namely DQw7 and DQw8, were analysed in patients of mixed ancestry (Cape Coloureds) with rheumatoid arthritis and in healthy individuals from the same population group using a DQ beta-specific cDNA probe. The DQw7 allele, identified by 3,4 kb Hind III or 3,7 kb and 6,9 kb Bam HI DQ beta-specific restriction fragments, was expressed in 93% of DR4-positive patients (N...
Topics
- Alleles
- Arthritis, Rheumatoid
- DNA Probes, HLA
- Female
- HLA-DQ Antigens
- HLA-DR4 Antigen
- Haplotypes
- Humans
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length