Article
Evidence of a strong, positive association between atopy and the HLA class II alleles DR4 and DR7.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jul 1996
Aron Y, Desmazes-Dufeu N, Matran R, Polla B S, Dusser D, Lockhart A, Swierczewski E
Abstract excerpt
BACKGROUND: Atopy, with or without associated asthma, provides a useful model for evaluating the genetic factors that control human immune responsiveness. HLA class II gene products are involved in the control of immune responses. OBJECTIVES: We investigated whether susceptibility or resistance t...
Topics
- Adult
- Alleles
- Asthma
- Case-Control Studies
- Disease Susceptibility
- Female
- Genetic Predisposition to Disease
- HLA-DP Antigens
- HLA-DP beta-Chains
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- HLA-DR4 Antigen
- HLA-DR7 Antigen
- Histocompatibility Antigens Class II
- Humans
- Hypersensitivity
- Male