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Article

Uracil-DNA glycosylase-deficient yeast exhibit a mitochondrial mutator phenotype.

Nucleic acids research - 15 Dec 2001

Chatterjee A, Singh K K

Abstract excerpt

Mutations in mitochondrial DNA (mtDNA) have been reported in cancer and are involved in the pathogenesis of many mitochondrial diseases. Uracil-DNA glycosylase, encoded by the UNG1 gene in Saccharomyces cerevisiae, repairs uracil in DNA formed due to deamination of cytosine. Our study demonstrates that inactivation of the UNG1 gene leads to at least a 3-fold increased frequency of mutations in mtDNA compared with...

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Source

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Identifiers

PMID: 11812822
DOI: 10.1093/nar/29.24.4935
PMCID: PMC97606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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