Article
[The effect of ablation of the gene for H+-Transporting NAD/NADP transhydrogenase on the life spans of nematodes and mammals].
Bioorganicheskaia khimiia - 1 Jan 2000
Pestov N B, Shakhparonov M I
Abstract excerpt
Mitochondrial transhydrogenase catalyzes the reaction H(+)(out) + NADP(+) + NADH = NAD(+) + NADPH + H(+)(in). The maintenance of the NADPH pool increases the mitochondrial antioxidant potential. Therefore, according to the commonly adopted free radical theory of aging, ablation of the transhydrogenase gene should reduce the life span. However, contrary to this reasoning, the life span of Caenorhabditis elegans...
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