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Article

Purkinje cell compartmentalization in the cerebellum of the spontaneous mutant mouse dreher.

Brain structure & function - 1 Jan 2014

Sillitoe Roy V, George-Jones Nicholas A, Millen Kathleen J, Hawkes Richard

Abstract excerpt

The cerebellar morphological phenotype of the spontaneous neurological mutant mouse dreher (Lmx1a(dr-J)) results from cell fate changes in dorsal midline patterning involving the roof plate and rhombic lip. Positional cloning revealed that the gene Lmx1a, which encodes a LIM homeodomain protein, is mutated in dreher, and is expressed in the developing roof plate and rhombic lip. Loss of Lmx1a causes reduction of...

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Identifiers

PMID: 23160833
DOI: 10.1007/s00429-012-0482-6
PMCID: PMC4140632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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