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Article

Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar).

Development (Cambridge, England) - 1 Jan 2000

Reifers F, Walsh E C, Léger S, Stainier D Y, Brand M

Abstract excerpt

Vertebrate heart development is initiated from bilateral lateral plate mesoderm that expresses the Nkx2.5 and GATA4 transcription factors, but the extracellular signals specifying heart precursor gene expression are not known. We describe here that the secreted signaling factor Fgf8 is expressed in and required for development of the zebrafish heart precursors, particularly during initiation of cardiac gene...

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Source

Identifiers

PMID: 10603341
DOI: 10.1242/dev.127.2.225

Genes

GATA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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