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Article

Differential effects of RASA3 mutations on hematopoiesis are profoundly influenced by genetic background and molecular variant.

PLoS genetics - 1 Dec 2020

Robledo Raymond F, Ciciotte Steven L, Graber Joel H, Zhao Yue, Lambert Amy J, Gwynn Babette, Maki Nathaniel J, Brindley Elena C, Hartman Emily, Blanc Lionel, Peters Luanne L

Abstract excerpt

Studies of the severely pancytopenic scat mouse model first demonstrated the crucial role of RASA3, a dual RAS and RAP GTPase activating protein (GAP), in hematopoiesis. RASA3 is required for survival in utero; germline deletion is lethal at E12.5-13.5 due to severe hemorrhage. Here, conditional deletion in hematopoietic stem and progenitor cells (HSPCs) using Vav-iCre recapitulates the null phenotype...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33370780
DOI: 10.1371/journal.pgen.1008857
PMCID: PMC7793307

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