Article
Direct determination of single nucleotide polymorphism haplotype of NFKBIL1 promoter polymorphism by DNA conformation analysis and its application to association study of chronic inflammatory diseases.
Human immunology - 1 Jan 2000
Shibata Hiroki, Yasunami Michio, Obuchi Nobuhisa, Takahashi Megumi, Kobayashi Yasushi, Numano Fujio, Kimura Akinori
Abstract excerpt
We previously revealed that one of the human leukocyte antigen-linked susceptibility genes for Takayasu's arteritis (TA) was mapped between TNFA and MICB loci and that -63T allele of NFKBIL1, which is between TNFA and MICB loci, was associated with rheumatoid arthritis (RA) in the Japanese population. We have developed a novel typing method based on reference strand-mediated conformation analysis for the upstream...
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