Article
MICA polymorphisms and decreased expression of the MICA receptor NKG2D contribute to idiopathic pulmonary fibrosis susceptibility.
Human genetics - 1 Jun 2009
Aquino-Galvez Arnoldo, Pérez-Rodríguez Martha, Camarena Angel, Falfan-Valencia Ramces, Ruiz Víctor, Montaño Martha, Barrera Lourdes, Sada-Ovalle Isabel, Ramírez Remedios, Granados Julio, Pardo Annie, Selman Moisés
Abstract excerpt
Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disorder of unknown etiology. IPF is likely the result of complex interrelationships between environmental and host factors, although the genetic risk factors are presently uncertain. Because we have found that some MHC polymorphisms confer susceptibility to IPF, in the present study we aimed to evaluate the role of the MHC class I chain-related...
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