Article
Correlation of mutations of oncogene C-Ha-ras at codon 12 with metastasis and survival of gastric cancer patients.
Oncogene research - 1 Jan 1991
Deng G R, Liu X H, Wang J R
Abstract excerpt
Mutations of c-Ha-ras at codon 12 were detected from 11 out of 27 fresh tissues and cell-lines of human gastric cancer patients using PCR-restriction analysis. Further statistical investigation showed that the presence of point mutations was related to the distal metastases and the survival time of gastric cancer patients after surgical operations.
Topics
- Electrophoresis, Polyacrylamide Gel
- Genes, ras
- Humans
- Mutation
- Neoplasm Metastasis
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Stomach Neoplasms
