Article
Genotype-by-sex interaction in the regulation of high-density lipoprotein: the Framingham Heart Study.
Human biology - 1 Dec 2005
Mosher M J, Martin L J, Cupples L A, Yang Q, Dyer T D, Williams J T, North K E
Abstract excerpt
Low levels of high-density lipoprotein (HDL) are widely documented as a risk factor for cardiovascular disease (CVD). Furthermore, there is marked sexual dimorphism in both HDL levels and the prevalence of CVD. However, the extent to which genetic factors contribute to such dimorphism has been largely unexplored. We examined the evidence for genotype-by-sex effects on HDL in a longitudinal sample of 1562...
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