Article
Systematic, genome-wide, sex-specific linkage of cardiovascular traits in French Canadians.
Hypertension (Dallas, Tex. : 1979) - 1 Apr 2008
Seda Ondrej, Tremblay Johanne, Gaudet Daniel, Brunelle Pierre-Luc, Gurau Alexandru, Merlo Ettore, Pilote Louise, Orlov Sergei N, Boulva Francis, Petrovich Milan, Kotchen Theodore A, Cowley Allen W, Hamet Pavel
Abstract excerpt
The sexual dimorphism of cardiovascular traits, as well as susceptibility to a variety of related diseases, has long been recognized, yet their sex-specific genomic determinants are largely unknown. We systematically assessed the sex-specific heritability and linkage of 539 hemodynamic, metabolic, anthropometric, and humoral traits in 120 French-Canadian families from the Saguenay-Lac-St-Jean region of Quebec,...
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