Article
Definition of novel GP6 polymorphisms and major difference in haplotype frequencies between populations by a combination of in-depth exon resequencing and genotyping with tag single nucleotide polymorphisms.
Journal of thrombosis and haemostasis : JTH - 1 Jun 2006
Watkins N A, O'Connor M N, Rankin A, Jennings N, Wilson E, Harmer I J, Davies L, Smethurst P A, Dudbridge F, Farndale R W, Ouwehand W H
Abstract excerpt
BACKGROUND: Common genetic variants of cell surface receptors contribute to differences in functional responses and disease susceptibility. We have previously shown that single nucleotide polymorphisms (SNPs) in platelet glycoprotein VI (GP6) determine the extent of response to agonist. In addition, SNPs in the GP6 gene have been proposed as risk factors for coronary artery disease. METHODS: To completely...
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