Article
Common gene variants in ASGR1 gene locus associate with reduced cardiovascular risk in absence of pleiotropic effects
6 Jul 2020
Abstract excerpt
BACKGROUND AND AIMS: The rare ASGR1 del12 variant is associated with a beneficial effect on coronary artery disease (CAD) that is disproportionate to the small reductions in plasma LDL cholesterol (LDLc). This unexplained benefit has sparked the debate on potential additional pleiotropic effects of ASGR1 variants. Since ASGR1 has also been implicated in platelet homeostasis, we evaluated platelet function in...
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