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Article

Identification of variation in the platelet transcriptome associated with glycoprotein 6 haplotype.

Platelets - 1 Jun 2008

Burns Philippa, Gusnanto Arief, Macaulay Iain C, Rankin Angela, Tom Brian, Langford Cordelia F, Dudbridge Frank, Ouwehand Willem H, Watkins Nicholas A

Abstract excerpt

Platelet Glycoprotein VI (GPVI) is the activatory collagen signalling receptor that transmits an outside-in signal via the FcR gamma-chain. In Caucasians two GP6 haplotypes have been identified which encode GPVI isoforms that differ by five amino-acids. The minor haplotype is associated with a modest but statistically significant reduction in GPVI abundance and reduced downstream signalling events. As GPVI is...

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Source

Identifiers

PMID: 18569861
DOI: 10.1080/09537100801947434

Genes

TUBB1
VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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