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Article

CD8+ T cell homing to the pancreas in the nonobese diabetic mouse is CD4+ T cell-dependent

1 Jan 1991

Abstract excerpt

The adoptive transfer of type I diabetes in nonobese diabetic mice requires the contribution of both CD4+ and CD8+ T cells. To further elucidate the cellular pathway(s) of beta-cell destruction and the responsibility of each subset, high doses of committed T cells from diabetic mice purified to single subsets, were injected into syngeneic nonobese diabetic neonates. The recipients of single or mixed subsets were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1670607
DOI: 10.4049/jimmunol.146.1.85

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