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Article

Sex-specific effect of insulin-dependent diabetes 4 on regulation of diabetes pathogenesis in the nonobese diabetic mouse.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2005

Ivakine Evgueni A, Fox Casey J, Paterson Andrew D, Mortin-Toth Steven M, Canty Angelo, Walton David S, Aleksa Katarina, Ito Shinya, Danska Jayne S

Abstract excerpt

Many human autoimmune diseases are more frequent in females than males, and their clinical severity is affected by sex hormone levels. A strong female bias is also observed in the NOD mouse model of type I diabetes (T1D). In both NOD mice and humans, T1D displays complex polygenic inheritance and T cell-mediated autoimmune pathogenesis. The identities of many of the insulin-dependent diabetes (Idd) loci, their...

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PMID: 15905556
DOI: 10.4049/jimmunol.174.11.7129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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