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Article

Differential impact of T cell repertoire diversity in diabetes-prone or -resistant IL-10 transgenic mice.

Cellular immunology - 1 May 1999

Balasa B, Lee J, Sarvetnick N

Abstract excerpt

Expression of IL-10 transgene (tg) in pancreatic beta cells failed to induce autoimmune insulitis and diabetes in (BALB/c x NOD)F1 mice. However, IL-10-expressing tg littermates from backcrosses (N2 and N3) with NOD mice became diabetic at 5 to 10 weeks of age in an MHC-dependent manner. In this study, we tested the possibility that enhancement in frequency of islet antigen (Ag)-specific T cells overrides the...

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Identifiers

PMID: 10222059
DOI: 10.1006/cimm.1999.1484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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