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Article

Stoichiometric analysis of the TM2 6' phenylalanine mutation on desensitization in alpha1beta2 and alpha1beta2gamma2 GABA A receptors.

Neuroscience letters - 31 Jan 2008

Gonzales Eric B, Bell-Horner Cathy L, Dibas Mohammed I, Huang Ren-Qi, Dillon Glenn H

Abstract excerpt

The presence of phenylalanine (F) at the 6' position of transmembrane domain 2 (TM2) in the alpha4 subunit of alpha4beta2 nicotinic receptors enhances desensitization. As the GABA A receptor affords the ability to study the influence of as few as one and as many as five Fs at this position, we have used it to investigate potential subunit- and stoichiometry-dependent effects of the TM2 6'F mutation on...

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Identifiers

PMID: 18162311
DOI: 10.1016/j.neulet.2007.11.039
PMCID: PMC2696071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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