Use of DNA Arrays to Identify a Mutation in the Negative Regulator,csrR,Responsible for the High Virulence of a Naturally Occurring Type M3 Group A Streptococcus Clinical Isolate

Abstract excerpt

We previously reported that type M3 group A streptococcus (GAS) showed a wide range of 50% lethal dose values in mice. Analysis using DNA arrays indicated that the most virulent strain, M3-f, expressed significantly higher levels of the products of several virulence genes than did the other M3 isolates. Sequencing of the csrS, csrR, luxS, and rgg genes in the isolates showed that the M-3f csrR gene contained a...

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