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Prophage Induction and Expression of Prophage-EncodedVirulence Factors in Group A Streptococcus Serotype M3 StrainMGAS315

25 Nov 2003

Abstract excerpt

The genome of the highly virulent group A Streptococcus (GAS) serotype M3 strain MGAS315 has six prophages that encode six proven or putative virulence factors. We examined prophage induction and expression of prophage-encoded virulence factors by this strain under in vitro conditions inferred to approximate in vivo conditions. Coculture of strain MGAS315 with Detroit 562 (D562) human epithelial pharyngeal cells...

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PMID: 14638798
DOI: 10.1128/iai.71.12.7079-7086.2003

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