Spontaneous Mutations in the CsrRS Two‐Component Regulatory System of<i>Streptococcus pyogenes</i>Result in Enhanced Virulence in a Murine Model of Skin and Soft Tissue Infection

Abstract excerpt

CsrS/CsrR is a 2-component system in Streptococcus pyogenes that negatively regulates hyaluronic capsule and several exotoxins. To detect spontaneous mutations in csrRS, mucoid and large colony variants of M1 strain MGAS166 were isolated from experimental murine skin infections. By use of complementation with a csrRS(+) plasmid, relevant mutations were also detected in 7 of 12 human clinical isolates. The...

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