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Article

Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Dec 2009

Treviño Lisa R, Shimasaki Noriko, Yang Wenjian, Panetta John C, Cheng Cheng, Pei Deqing, Chan Diana, Sparreboom Alex, Giacomini Kathleen M, Pui Ching-Hon, Evans William E, Relling Mary V

Abstract excerpt

PURPOSE: Methotrexate plasma concentration is related to its clinical effects. Our aim was to identify the genetic basis of interindividual variability in methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: We performed a genome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19901119
DOI: 10.1200/JCO.2008.20.4156
PMCID: PMC2793040

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19901119-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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