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Article

Runaway domain swapping in amyloid-like fibrils of T7 endonuclease I.

Proceedings of the National Academy of Sciences of the United States of America - 23 May 2006

Guo Zhefeng, Eisenberg David

Abstract excerpt

Amyloid fibrils are associated with >20 fatal human disorders, including Alzheimer's, Parkinson's, and prion diseases. Knowledge of how soluble proteins assemble into amyloid fibrils remains elusive despite its potential usefulness for developing diagnostics and therapeutics. In at least some fibrils, runaway domain swapping has been proposed as a possible mechanism for fibril formation. In runaway domain...

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Identifiers

PMID: 16698921
DOI: 10.1073/pnas.0602607103
PMCID: PMC1472426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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