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Article

Is amyloid fibrillation related to 3D domain swapping for the C-terminal domain of SARS-CoV main protease?

International journal of biological macromolecules - 1 Feb 2022

Yuan Zhiliang, Qu Zhi, Duan Bo, Wang Tianyi, Xu Jiajun, Xia Bin

Abstract excerpt

The C-terminal domain of SARS-CoV main protease (Mpro-C) can form 3D domain-swapped dimer by exchanging the α1-helices fully buried inside the protein hydrophobic core, under non-denaturing conditions. Here, we report that Mpro-C can also form amyloid fibrils under the 3D domain-swappable conditions in vitro, and the fibrils are not formed through runaway/propagated domain swapping. It is found that there are...

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Identifiers

PMID: 34953805
DOI: 10.1016/j.ijbiomac.2021.12.072
PMCID: PMC8694786

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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