Article

HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF-Transcriptional Mediated Neurodegeneration

2020-07-06

Abstract excerpt

HIV infection and drugs of abuse induce oxidative stress and redox imbalance, which cause neurodegeneration. The mechanisms by which HIV infection and cocaine consumption affect astrocytes energy metabolism lead neurodegenerative dysfunction remain poorly understood. We investigated how oxidative injury cause energy resource and depletion of glutathione synthetase (GSS), activating energy sensor AMPK-mediated glyc...

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Literature Corpus work: 70a72f8e-8785-5681-989d-1ee962ffa9c2
DOI: 10.21203/rs.3.rs-38931/v1

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