Article
Evaluation of novel Brucella melitensis unmarked deletion mutants for safety and efficacy in the goat model of brucellosis.
Vaccine - 12 Jun 2006
Kahl-McDonagh Melissa M, Elzer Philip H, Hagius Sue D, Walker Joel V, Perry Quinesha L, Seabury Christopher M, den Hartigh Andreas B, Tsolis Renee M, Adams L Garry, Davis Donald S, Ficht Thomas A
Abstract excerpt
Pregnant goats were employed to assess unmarked deletion mutant vaccine candidates BMDeltaasp24, BMDeltacydBA, and BMDeltavirB2, as the target host species naturally infected with Brucella melitensis. Goats were assessed for the degree of pathology associated with the vaccine strains as well as the protective immunity afforded by each strain against abortion and infection after challenge with wild-type Brucella...
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