Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Safety and Immunogenicity of Recombinant Bacille Calmette-Guérin Strain VPM1002 and Its Derivatives in a Goat Model

14 Mar 2023

Abstract excerpt

A more effective vaccine against tuberculosis than Bacille Calmette-Guérin (BCG) is urgently needed. BCG derived recombinant VPM1002 has been found to be more efficacious and safer than the parental strain in mice models. Newer candidates, such as VPM1002 Δpdx1 (PDX) and VPM1002 ΔnuoG (NUOG), were generated to further improve the safety profile or efficacy of the vaccine. Herein, we assessed the safety and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Response and Inflammation
Share to Immune responses and vaccinations
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36982586
DOI: 10.3390/ijms24065509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Safety and Immunogenicity of Recombinant Bacille Calmette-Guérin Strain VPM1002 and Its Derivatives in a Goat ModelPMID 36982586Read ↗

Development of a PPRV challenge model in goats and its use to assess the efficacy of a PPR vaccineSemantic proximity Read ↗

Recombinant BCG: innovations on an old vaccine. Scope of BCG strains and strategies to improve long-lasting memorySemantic proximity Read ↗

Development of innovative multi-epitope mRNA vaccine against central nervous system tuberculosis using in silico approachesSemantic proximity Read ↗

Genomic characteristics of two most widely used BCG vaccine strains: Danish 1331 and Pasteur 1173P2Semantic proximity Read ↗

Improved Immune Responses and Tuberculosis Protection by Aerosol Vaccination with recombinant BCG expressing ESX-1 from <i>Mycobacterium marinum</i>Semantic proximity Read ↗

Modified vaccinia Ankara‐expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4<sup>+</sup> T cellsSemantic proximity Read ↗

Advances in protein subunit vaccines against tuberculosisSemantic proximity Read ↗

BCG vaccine’s off-target effects on allergic, inflammatory, and autoimmune diseases: Worth another shot?Semantic proximity Read ↗

BCG VaccinesSemantic proximity Read ↗

A proof-of-concept study to investigate the efficacy of heat-inactivated autovaccines in Mycobacterium caprae experimentally challenged goatsSemantic proximity Read ↗

Evaluation of novel Brucella melitensis unmarked deletion mutants for safety and efficacy in the goat model of brucellosis.Semantic proximity Read ↗

Newly sequenced genomes of four Bacillus Calmette Guerin vaccines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.