Article
A rational framework for evaluating the next generation of vaccines against Mycobacterium avium subspecies paratuberculosis.
Frontiers in cellular and infection microbiology - 1 Jan 2014
Bannantine John P, Hines Murray E, Bermudez Luiz E, Talaat Adel M, Sreevatsan Srinand, Stabel Judith R, Chang Yung-Fu, Coussens Paul M, Barletta Raúl G, Davis William C, Collins Desmond M, Gröhn Yrjö T, Kapur Vivek
Abstract excerpt
Since the early 1980s, several investigations have focused on developing a vaccine against Mycobacterium avium subspecies paratuberculosis (MAP), the causative agent of Johne's disease in cattle and sheep. These studies used whole-cell inactivated vaccines that have proven useful in limiting disease progression, but have not prevented infection. In contrast, modified live vaccines that invoke a Th1 type immune...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.