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Article

Superior Protection from Live-Attenuated Vaccines Directed against Johne's Disease.

Clinical and vaccine immunology : CVI - 1 Jan 2017

Shippy Daniel C, Lemke Justin J, Berry Aubrey, Nelson Kathryn, Hines Murray E, Talaat Adel M

Abstract excerpt

Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) is the etiological agent of Johne's disease in ruminants. Johne's disease is an important enteric infection causing large economic losses associated with infected herds. In an attempt to fight this infection, we created two novel live-attenuated vaccine candidates with mutations in sigH and lipN (pgsH and pgsN, respectively). Earlier reports in...

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Source

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Identifiers

PMID: 27806993
DOI: 10.1128/CVI.00478-16
PMCID: PMC5216426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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