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Article

Atypical Protein Kinase C in Neurodegenerative Disease I

1 Apr 2006

Abstract excerpt

Protein kinase Mzeta (PKMzeta), an atypical protein kinase C (PKC) isoform, plays a key role in the maintenance of long-term potentiation (LTP), a persistent enhancement of AMPA receptor-mediated synaptic transmission, as well as in the persistence of memory in Drosophila. Because memory impairment in Alzheimer disease (AD) has been attributed to disruption of synaptic plasticity, we investigated the expression...

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PMID: 16691113
DOI: 10.1097/01.jnen.0000218442.07664.04

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