Article
Molecular assessment of drug resistance in Plasmodium falciparum from Bahr El Gazal province, Sudan.
Tropical medicine & international health : TM & IH - 1 Dec 2003
Anderson Tim J C, Nair Shalini, Jacobzone Corine, Zavai Andes, Balkan Suna
Abstract excerpt
AIMS: To assess resistance to chloroquine (CQ) and sulphadoxine/pyrimethamine (SP) in a Sudanese parasite population. METHODS: Recurrent security problems in Akuem, Sudan, prevented us from conducting a classical in vivo treatment efficacy study. Instead we genotyped key mutations in the chloroquine resistance transporter (pfcrt), the multidrug resistance gene (pfmdr1), dihydrofolate reductase (dhfr) and...
Topics
- ATP-Binding Cassette Transporters
- Animals
- Antimalarials
- Chloroquine
- Dihydropteroate Synthase
- Drug Combinations
- Drug Resistance
- Gene Frequency
- Genotype
- Humans
- Membrane Proteins
- Membrane Transport Proteins
- Mutation
- Plasmodium falciparum