Article
Frequency distribution of antimalarial drug resistance alleles among Plasmodium falciparum isolates from Gezira State, central Sudan, and Gedarif State, eastern Sudan.
The American journal of tropical medicine and hygiene - 1 Aug 2010
Menegon Michela, Talha Albadawi A, Severini Carlo, Elbushra Sayed M, Mohamedani Ahmed A, Malik Elfatih M, Mohamed Tarig A, Wernsdorfer Walther H, Majori Giancarlo, Nour Bakri Y M
Abstract excerpt
In 2004, Sudan adopted artesunate + sulfadoxine/pyrimethamine (SP) combination as the first-line drug, in response to the high level of falciparum resistance to antimalarials. In 2007, a molecular study on antimalarial resistance linked genes, pfcrt, pfmdr1, pfdhfr, pfdhps, and pfATPase6, was conducted on 198 isolates from central and eastern Sudan. We observed a high frequency of point mutations at almost all...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.