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Article

Concurrence of Plasmodium falciparum dhfr and crt mutations in northern Ghana.

Malaria journal - 15 Sept 2005

Mockenhaupt Frank P, Bousema J Teun, Eggelte Teunis A, Ehrhardt Stephan, Otchwemah Rowland N, Sauerwein Robert W, Bienzle Ulrich

Abstract excerpt

BACKGROUND: Both chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) are failing drugs in much of sub-Saharan Africa. Previous findings suggest an association between resistance to CQ and to SP in vivo, in vitro, and on the molecular level. METHODS: In 126 Ghanaian children with uncomplicated malaria, associations between mutations conferring resistance in the Plasmodium falciparum dihydrofolate reductase (dhfr;...

Topics

Animals
Antimalarials
Child, Preschool
Chloroquine
Drug Resistance
Female
Ghana
Humans
Infant
Malaria
Male
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Transport Proteins

Mutation

Plasmodium falciparum

Protozoan Proteins

Tetrahydrofolate Dehydrogenase

Source

Open in PubMed Open full text

Identifiers

PMID: 16164748
DOI: 10.1186/1475-2875-4-42
PMCID: PMC1261531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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