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Article

Self-association of Calcium-binding Protein S100A4 and Metastasis

17 Nov 2009

Abstract excerpt

Elevated levels of the calcium-binding protein S100A4 promote metastasis and in carcinoma cells are associated with reduced survival of cancer patients. S100A4 interacts with target proteins that affect a number of activities associated with metastatic cells. However, it is not known how many of these interactions are required for S100A4-promoted metastasis, thus hampering the design of specific inhibitors of...

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PMID: 19917604
DOI: 10.1074/jbc.m109.010892

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