Illustration of the effects of genotype misclassification on the measurement of familial aggregation in epidemiologic studies.

doi:10.1097/00001648-199001000-00012

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Article

Illustration of the effects of genotype misclassification on the measurement of familial aggregation in epidemiologic studies.

Epidemiology (Cambridge, Mass.) - 1 Jan 1990

Khoury M J, Flanders W D

Abstract excerpt

Exposure misclassification is a well-known problem in epidemiologic studies and can considerably dilute relative risk (RR) measures toward unity. A vivid illustration of such misclassification occurs in familial aggregation studies, where "exposure" is defined as a specified genetic relationship...

Topics

Classification
Epidemiologic Methods
Gene Frequency
Genetic Diseases, Inborn
Genetic Markers
Genotype
Humans
Models, Genetic
Models, Statistical
Predictive Value of Tests
Risk Factors

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